Centers for Biological Intelligence
The AnnieGuard Institute is organized around focused research centers dedicated to understanding disease at its biological core. Each center advances a distinct area of investigation, unified by a common framework: biology-first intelligence, longitudinal analysis, and mechanistic discovery.
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Rather than organizing research by traditional clinical silos, AnnieGuard centers are structured around how disease behaves, evolves, and escapes detection—allowing for deeper insight into rare, complex, and poorly understood conditions.
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Our centers operate at the intersection of biology, computation, and translational research, generating foundational knowledge that informs future diagnostics, therapeutic strategies, and clinical decision-making.
Sarcoma Research Focus
Current Areas of Focus
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Early Biological Detection
Identifying molecular and structural signals that emerge before clinical symptoms or imaging changes.
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Chromosomal Instability & Disease Architecture
Studying how large-scale genomic disruption, rather than single mutations, drives sarcoma development and progression.
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Age-Stratified Disease Biology
Understanding how sarcoma behaves differently across pediatric, adolescent, and adult populations.
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Computational Disease Modeling
Reconstructing disease behavior using biological-first computational frameworks rather than purely statistical models.
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Translational Insight
Connecting biological discovery to future diagnostic strategy, risk stratification, and therapeutic decision-making.