Biology-First Intelligence

Advancing how disease is understood, interpreted, and acted upon.

Redefining disease through biological intelligence and systems-level research.

The AnnieGuard Institute for Biological Intelligence advances a new way of understanding disease — one that prioritizes biological behavior, temporal dynamics, and system-level signals over static diagnosis.

Our work focuses on identifying how risk evolves, how biological systems adapt, and why early signals are often missed by traditional models.

By studying disease as a living process rather than a fixed state, we aim to enable earlier insight, more precise interpretation, and more informed intervention.

About the Institute

Latest Research

Why Single-Agent EGFR Inhibition May Fail in Dual-Driver Tumors

We outline how EGFR-KDD tumors evade targeted therapy through dual oncogenic signaling, highlighting the limits of single-agent TKIs and the need for combination strategies across tumor types.

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Age-Dependent Chromosomal Instability in Osteosarcoma

Our findings reveal that osteosarcoma behaves differently across the lifespan—where early genomic chaos, not cumulative damage, may drive disease in younger patients.

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Age-Stratified Molecular Classification of Ewing Sarcoma

Our study demonstrates that Ewing sarcoma is not a single disease, but a set of biologically distinct subtypes defined by age, genomic instability, and molecular behavior—challenging long-held assumptions about uniform treatment response.

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